UHN COMBIEL

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Research at Princess Margaret Hospital
University Health Network
610 University Ave
Toronto, M5A 3W7
Canada

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PUBLICATIONS

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  1. Shepshelovich D, Xu W, Lu L, Fares A, Yang P, Christiani D, Zhang J, Shiraishi K, Ryan BM, Chen C, Schwartz AG, Tardon A, Wu X, Schabath MB, Teare MD, Le Marchand L, Zhang ZF, Field JK, Brenner H, Daio N, Xie J, Kohno T, Harris CC, Wenzlaff AS, Fernandez-Tardon G, Ye Y, Taylor F, Wilkens LR, Davies M, Liu Y, Barnett MJ, Goodman GE, Morgenstern H, Holleczek B, Brown MC, Liu G, Hung R. Body mass index (BMI), BMI change, and overall survival in small cell and non-small cell lung cancer patients: a pooled analysis of the International Lung Cancer Consortium. J Thorac Oncol. 2019 Jun 1. pii: S1556-0864(19)30416-2. doi: 10.1016/j.jtho.2019.05.031.

  2. Giuliani M, Brual J, Eng L, Liu G, Papadakos T, Giannopoulos E, Papadakos J.Investigating the Smoking Cessation Informational Needs of Cancer Patients and Informal Caregivers.J Cancer Educ. 2019 May 22. doi: 10.1007/s13187-019-01547-w.

  3. Zazuli Z, Otten LS, Drögemöller BI, Medeiros M, Monzon JG, Wright GEB, Kollmannsberger CK, Bedard PL, Chen Z, Gelmon KA, McGoldrick N, Kitchlu A, Vijverberg SJH, Masereeuw R, Ross CJD, Liu G, Carleton BC, Maitland-van der Zee AH.Outcome Definition Influences the Relationship Between Genetic Polymorphisms of <i>ERCC1</i>, <i>ERCC2</i>, <i>SLC22A2</i> and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients.Genes (Basel). 2019 May 10;10(5). pii: E364. doi: 10.3390/genes10050364.

  4. O'Kane GM, Liu G, Stockley TL, Shabir M, Zhang T, Law JH, Le LW, Sacher A, Shepherd FA, Bradbury PA, Leighl NB.The presence and variant allele fraction of EGFR mutations in ctDNA and development of resistance.Lung Cancer. 2019 May;131:86-89. doi: 10.1016/j.lungcan.2019.03.019. Epub 2019 Mar 20.

  5. Giuliani ME, Liu G, Xu W, Dirlea M, Selby P, Papadakos J, Abdelmutti N, Yang D, Eng L, Goldstein DP, Jones JM. Implementation of a Novel Electronic Patient-Directed Smoking Cessation Platform for Cancer Patients: Interrupted Time Series Analysis.J Med Internet Res. 2019 Apr 9;21(4):e11735. doi: 10.2196/11735.

  6. O'Kane GM, Su J, Tse BC, Tam V, Tse T, Lu L, Borean M, Tam E, Labbé C, Naik H, Mittmann N, Doherty MK, Bradbury PA, Leighl NB, Shepherd FA, Richard NM, Edelstein K, Shultz D, Brown MC, Xu W, Howell D, Liu G. The Impact of Brain Metastases and Associated Neurocognitive Aspects on Health Utility Scores in EGFR Mutated and ALK Rearranged NSCLC: A Real World Evidence Analysis. Oncologist. 2019 Apr 5. pii: theoncologist.2018-0544. doi: 10.1634/theoncologist.2018-0544.

  7.       Liu SY, Lu L, Pringle D, Mahler M, Niu C, Charow R, Tiessen K, Lam C, Halytskyy O, Naik H, Hon H, Irwin M, Pat V, Gonos C, Chan CWT, Villeneuve J, Shani RM, Chaudhry M, Brown MC, Selby P, Howell D, Xu W, Alibhai SMH, Jones JM, Liu G, Eng L. Impact of immigration status on health behaviors and perceptions in cancer survivors. Cancer Med. 2019 May;8(5):2623-2635. doi: 10.1002/cam4.2079. Epub 2019 Mar 21.

  8. Ezeife DA, Morganstein BJ, Lau S, Law JH, Le LW, Bredle J, Cella D, Doherty MK, Bradbury P, Liu G, Sacher A, Shepherd FA, Leighl NB. Financial Burden Among Patients With Lung Cancer in a Publically Funded Health Care System. Clin Lung Cancer. 2018 Dec 22. pii: S1525-7304(18)30334-6. doi: 10.1016/j.cllc.2018.12.010. 

  9. Aggarwal R, Lam ACL, McGregor M, Menezes R, Hueniken K, Tateishi H, O'Kane GM, Tsao MS, Shepherd FA, Xu W, McInnis M, Schmidt H, Liu G, Kavanagh J. Outcomes of Long-term Interval Rescreening With Low-Dose Computed Tomography for Lung Cancer in Different Risk Cohorts. J Thorac Oncol. 2019 Jun;14(6):1003-1011. doi: 10.1016/j.jtho.2019.01.031. Epub 2019 Feb 13.

  10. Tomasini P, Mascaux C, Jao K, Labbe C, Kamel-Reid S, Stockley T, Hwang DM, Leighl NB, Liu G, Bradbury PA, Pintilie M, Tsao MS, Shepherd FA. Effect of Coexisting KRAS and TP53 Mutations in Patients Treated With Chemotherapy for Non-small-cell Lung Cancer. Clin Lung Cancer. 2019 May;20(3):e338-e345. doi: 10.1016/j.cllc.2018.12.009. Epub 2018 Dec 19.

  11. 1Ren J, Yang W, Su J, Ren X, Fazelzad R, Albert T, Habbous S, Goldstein DP, de Almeida JR, Hansen A, Jang R, Bratman SV, Hope A, Chen R, Wang J, Xu Y, Cheng D, Zhao Y, Xu W, Liu G. Human papillomavirus and p16 immunostaining, prevalence and prognosis of squamous carcinoma of unknown primary in the head and neck region.

  12. Moradian S, Krzyzanowska MK, Maguire R, Morita PP, Kukreti V, Avery J, Liu G, Cafazzo J, Howell D. Usability Evaluation of a Mobile Phone-Based System for Remote Monitoring and Management of Chemotherapy-Related Side Effects in Cancer Patients: Mixed-Methods Study. JMIR Cancer. 2018 Dec 21;4(2):e10932. doi: 10.2196/10932.

  13. Shen SY, Singhania R, Fehringer G, Chakravarthy A, Roehrl MHA, Chadwick D, Zuzarte PC, Borgida A, Wang TT, Li T, Kis O, Zhao Z, Spreafico A, Medina TDS, Wang Y, Roulois D, Ettayebi I, Chen Z, Chow S, Murphy T, Arruda A, O'Kane GM, Liu J, Mansour M, McPherson JD, O'Brien C, Leighl N, Bedard PL, Fleshner N, Liu G, Minden MD, Gallinger S, Goldenberg A, Pugh TJ, Hoffman MM, Bratman SV, Hung RJ, De Carvalho DD. Sensitive tumour detection and classification using plasma cell-free DNA methylomes. Nature. 2018 Nov;563(7732):579-583. doi: 10.1038/s41586-018-0703-0. Epub 2018 Nov 14.

  14. Eng L, Pringle D, Su J, Espin-Garcia O, Niu C, Mahler M, Halytskyy O, Charow R, Lam C, Shani RM, Villeneuve J, Tiessen K, Dobriyal A, Zarrin A, Vennettilli A, Brown MC, Alibhai SMH, Howell D, Jones JM, Selby P, Xu W, Liu G. Patterns, perceptions and their association with changes in alcohol consumption in cancer survivors. Eur J Cancer Care (Engl). 2019 Jan;28(1):e12933. doi: 10.1111/ecc.12933. Epub 2018 Oct 16.

  15. Zazuli Z, Vijverberg S, Slob E, Liu G, Carleton B, Veltman J, Baas P, Masereeuw R, Maitland-van der Zee AH. Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review. Front Pharmacol. 2018 Sep 27;9:1111. doi: 10.3389/fphar.2018.01111. eCollection 2018.

  16. Shepshelovich D, Townsend AR, Espin-Garcia O, Latifovic L, O'Callaghan CJ, Jonker DJ, Tu D, Chen E, Morgen E, Price TJ, Shapiro J, Siu LL, Kubo M, Dobrovic A, Ratain MJ, Xu W, Mushiroda T, Liu G. Fc-gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer. Cancer Med. 2018 Nov;7(11):5478-5487. doi: 10.1002/cam4.1819. Epub 2018 Oct 14.

  17. Jao K, Tomasini P, Kamel-Reid S, Korpanty GJ, Mascaux C, Sakashita S, Labbé C, Leighl NB, Liu G, Feld R, Bradbury PA, Hwang DM, Pintilie M, Tsao MS, Shepherd FA. The prognostic effect of single and multiple cancer-related somatic mutations in resected non-small-cell lung cancer. Lung Cancer. 2018 Sep;123:22-29. doi: 10.1016/j.lungcan.2018.06.023. Epub 2018 Jun 19.

  18. Soldera SV, Shakik S, Naik H, Moskovitz M, Chen J, Mittmann N, Xu W, Hope A, Bezjak A, Parajian A, Keshavjee S, Liu G. Favourable health-related quality of life reported in survivors of thymic malignancies. Eur J Cardiothorac Surg. 2019 Feb 1;55(2):292-299. doi: 10.1093/ejcts/ezy259.

  19. Kachuri L, Saarela O, Bojesen SE, Davey Smith G, Liu G, Landi MT, Caporaso NE, Christiani DC, Johansson M, Panico S, Overvad K, Trichopoulou A, Vineis P, Scelo G, Zaridze D, Wu X, Albanes D, Diergaarde B, Lagiou P, Macfarlane GJ, Aldrich MC, Tardón A, Rennert G, Olshan AF, Weissler MC, Chen C, Goodman GE, Doherty JA, Ness AR, Bickeböller H, Wichmann HE, Risch A, Field JK, Teare MD, Kiemeney LA, van der Heijden EHFM, Carroll JC, Haugen A, Zienolddiny S, Skaug V, Wünsch-Filho V, Tajara EH, Ayoub Moysés R, Daumas Nunes F, Lam S, Eluf-Neto J, Lacko M, Peters WHM, Le Marchand L, Duell EJ, Andrew AS, Franceschi S, Schabath MB, Manjer J, Arnold S, Lazarus P, Mukeriya A, Swiatkowska B, Janout V, Holcatova I, Stojsic J, Mates D, Lissowska J, Boccia S, Lesseur C, Zong X, McKay JD, Brennan P, Amos CI, Hung RJ. Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. Int J Epidemiol. 2018 Jul 28. doi: 10.1093/ije/dyy140. [Epub ahead of print]

  20. Korpanty GJ, Kamel-Reid S, Pintilie M, Hwang DM, Zer A, Liu G, Leighl NB, Feld R, Siu LL, Bedard PL, Tsao MS, Shepherd FA. Lung cancer in never smokers from the Princess Margaret Cancer Centre. Oncotarget. 2018 Apr 27;9(32):22559-22570. doi: 10.18632/oncotarget.25176. eCollection 2018 Apr 27.

  21. Herman M, Warkentin MT, Shepshelovich D, Latifovic L, Hung R, Liu G. Heritable Germline Variation and Lung Cancer Susceptibility: One Size Does not Fit All. J Thorac Oncol. 2018 May;13(5):601-602. doi: 10.1016/j.jtho.2018.02.018. No abstract available.

  22. Drögemöller BI, Brooks B, Critchley C, Monzon JG, Wright GEB, Liu G, Renouf DJ, Kollmannsberger CK, Bedard PL, Hayden MR, Gelmon KA, Carleton BC, Ross CJD. Further Investigation of the Role of <i>ACYP2</i> and <i>WFS1</i> Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients. Clin Cancer Res. 2018 Apr 15;24(8):1866-1871. doi: 10.1158/1078-0432.CCR-17-2810. Epub 2018 Jan 22.

  23. Hall E, Tam E, Liang M, Zhang Q, Liu L, Wong L, Sarabia S, Yeung S, Gill G, Eng L, Perez-Cosio A, Brown MC, Xu W, Li M, Mittmann N, Jones J, Howell D, Liu G.Development and prospective evaluation of CAPLET, a cancer ambulatory patient physical function longitudinal evaluation tool for routine clinical practice. Support Care Cancer doi: 10.1007/s00520-018-4333-8, 2018

  24. Doherty MK, Leung Y, Su J, Naik H, Patel D, Eng L, Kong QQ, Mohsin F, Brown MC, Espin-Garcia O, Vennettilli A, Renouf DJ, Faluyi OO, Knox JJ, MacKay H, Wong R, Howell D, Mittmann N, Darling GE, Cella D, Xu W, Liu GHealth utility scores from EQ-5D and health-related quality of life in patients with esophageal cancer: a real-world cross-sectional study. Dis Esophagus doi: 10.1093/dote/doy058 [Epub ahead of print], 2018

  25. Borean M, Shani K, Brown MC, Chen J, Liang M, Karkada J, Kooner S, Doherty MK, O'Kane GM, Jang R, Elimova E, Wong RK, Darling GE, Xu W, Howell D, Liu G.  Development and Evaluation of Screening Dysphagia Tools for Observational Studies and Routine Care in Cancer Patients. Health Services Reports [in press], 2018

  26. Zer A, Sung MR, Walia P, Khoja L, Maganti M, Labbe C, Shepherd FA, Bradbury PA, Feld R, Liu G, Iazzi M, Zawisza D, Nouriany N, Leighl NB. Correlation of Neutrophil to Lymphocyte Ratio and Absolute Neutrophil Count With Outcomes With PD-1 Axis Inhibitors in Patients With Advanced Non-Small-Cell Lung Cancer. Clin Lung Cancer pii: S1525-7304(18)30090-1 [Epub ahead of print], 2018

  27. Eng L, Pringle D, Su J, Shen XW, Mahler M, Niu C, Charow R, Tiessen K, Lam C, Halytsky O, Naul H, Hon H, Irwin M, Pat V, Gonos C, Chan C, Villeneuve J, Harland L, Shani RM, Brown MC, Selby P, Howell D, Xu W, Liu G*, Alibhai SMF*, Jones JM*. Patterns, perceptions, and perceived barriers to physical activity in adult cancer survivors. Support Care Cancer doi: 10.1007/s00520-018-4239-5. [Epub ahead of print], 2018

  28. Teichman J, Dodbiba L, Thai H, Fleet A, Morey T, Liu L, McGregor M, Cheng D, Chen Z, Darling G, Brhane Y, Song Y, Espin-Garcia O, Xu W, Girgis H, Schwock J, MacKay H, Bristow R, Ailles L, Liu G. Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma. PLoS One 13:e019409, 2018

  29. Herman M, Warkentin MT, Shepshelovich D, Latifovic L, Hung R, Liu G. Heritable Germline Variation and Lung Cancer Susceptibility: One Size Does not Fit All. J Thorac Oncol 13:601-602, 2018

  30. Alton D, Eng L, Lu L, Song Y, Su J, Farzanfar D, Mohan R, Krys O, Mattina K, Harper C, Liu S, Yoannidis T, Milne R, Brown MC, Vennettilli A, Hope AJ, Howell D, Jones JM, Selby P, Xu W, Goldstein DP, Liu G, Giuliani ME. Perceptions of Continued Smoking and Smoking Cessation Among Patients With Cancer. J Oncol Pract JOP1700029 [Epub ahead of print], 2018

  31. Pasic I, Wong KM, Lee JJ, Espin-Garcia O, Brhane Y, Cheng D, Chen Z, Patel D, Brown C, Bucur R, Reisman D, Knox JJ, Xu W, Hung RJ, Liu G*, Cleary SP*. Two BRM promoter polymorphisms predict poor survival in patients with hepatocellular carcinoma. Mol Carcinog 1:106-113, 2018

  32. Spreafico A, Coate L, Zhai R, Xu W, Chen ZF, Chen Z, Patel D, Tse B, Brown MC, Heist RS, Dodbiba L, Teichman J, Kulke M, Su L, Eng L, Knox J, Wong R, Darling GE, Christiani DC, Liu G. Early adulthood body mass index, cumulative smoking, and esophageal adenocarcinoma survival. Cancer Epidemiol 47:28-34, 2017

  33. Zer A, Moskovitz M, Hwang DM, Hershko-Klement A, Fridel L, Korpanty GJ, Dudnik E, Peled N, Shochat T, Leighl NB, Liu G, Feld R, Burkes R, Wollner M, Tsao MS, Shepherd FA. ALK-Rearranged Non-Small-Cell Lung Cancer Is Associated With a High Rate of Venous Thromboembolism. Clin Lung Cancer 18:156-161, 2017

  34. Faluyi OO, Eng L, Qiu X, Che J, Zhang Q, Cheng D, Ying N, Tse A, Kuang Q, Dodbiba L, Renouf DJ, Marsh S, Savas S, Mackay HJ, Knoww JJ, Darling GE, Wong RK, Xu W, Azad AK, Liu G. Validation of microRNA pathway polymorphisms in esophageal adenocarcinoma survival. Cancer Medicine 6:361-373, 2017

  35. Naik H, Howell D, Su S, Qiu X, Brown MC, Vennettilli A, Irwin M, Pat V, Solomon H, Wang T, Hon H, Eng L, Mahler M, Thai H, Ho V, Xu W, Seung SJ, Mittmann N, Liu G: EQ-5D Health Utility Scores: Data from a Comprehensive Canadian Cancer Centre. The Patient - Patient-Centered Outcomes Research 10:105-115, 2017

  36. Labbé C, Cabanero M, Korpanty GJ, Tomasini P, Doherty MK, Mascaux C, Jao K, Pitcher B, Wang R, Pintilie M, Leighl NB, Feld R, Liu G, Bradbury PA, Kamel-Reid S, Tsao M-S, Shepherd FA: Prognostic and predictive effects of TP53 co-mutation in patients with EGFR-mutated non-small cell lung cancer (NSCLC). Lung Cancer 111:23-29, 2017

  37. Labbé C, Leung Y, Silva Lemes JG, Stewart E, Brown C, Cosio AP, Doherty M, O'Kane GM, Patel D, Cheng N, Liang M, Gill G, Rett A, Naik H, Eng L, Mittmann N, Leighl NB, Bradbury PA, Shepherd FA, Xu W, Liu G, Howell D: Real-World EQ5D Health Utility Scores for Patients With Metastatic Lung Cancer by Molecular Alteration and Response to Therapy. Clin Lung Cancer 18:388-395.e4, 2017

  38. O’Kane GM, Bradbury PA, Feld R, Leighl NB, Liu G, Pisters K-M, Kamel-Reid S, Tsao MS, Shepherd FA: Uncommon EGFR mutations in advanced non-small cell lung cancer. Lung Cancer 109:137-144, 2017

  39. Doherty MK, Korpanty GJ, Tomasini P, Alizadeh M, Jao K, Labbé C, Mascaux CM, Martin P, Kamel-Reid S, Tsao M-S, Pintilie M, Liu G, Bradbury PA, Feld R, Leighl NB, Chung C, Shepherd FA: Treatment options for patients with brain metastases from EGFR/ALK-driven lung cancer. Radiotherapy and Oncology 123:195-202, 2017

  40. Gama RR, Song Y, Zhang Q, Brown MC, Wang J, Habbous S, Tong L, Huang SH, O'Sullivan B, Waldron J, Xu W, Goldstein D, Liu G: Body mass index and prognosis in patients with head and neck cancer. Head & Neck 39:1226-1233, 2017

  41. Korpanty GJ, Eng L, Qiu X, Faluyi OO, Renouf DJ, Cheng D, Patel D, Chen Z, Tse BC, Knox JJ, Dodbiba L, Teichman J, Azad AK, Wong R, Darling G, Reisman D, Cuffe S, Liu G, Xu W: Association of BRM promoter polymorphisms and esophageal adenocarcinoma outcome. Oncotarget 8:28093-28100, 2017

  42. Habbous S, Chu KP, Lau H, Schorr M, Belayneh M, Ha MN, Murray S, O’Sullivan B, Huang SH, Snow S, Parliament M, Hao D, Cheung WY, Xu W, Liu G: Human papillomavirus in oropharyngeal cancer in Canada: analysis of 5 comprehensive cancer centres using multiple imputation. CMAJ : Canadian Medical Association Journal 189:E1030-E1040, 2017

  43. Martin P, Stewart E, Pham N-A, Mascaux C, Panchal D, Li M, Kim L, Sakashita S, Wang D, Sykes J, Friess T, Shepherd FA, Liu G, Tsao M-S: Cetuximab Inhibits T790M-Mediated Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in a Lung Adenocarcinoma Patient-Derived Xenograft Mouse Model. Clin Lung Cancer, 2016

  44. Cuffe S, Azad AK, Qiu X, Qiu X, Brhane Y, Kuang Q, Marsh S, Savas S, Chen Z, Cheng D, Leighl NB, Goss G, Laurie SA, Seymour L, Bradbury PA, Shepherd FA, Tsao MS, Chen BE, Xu W, Liu G: ABCC2 polymorphisms and survival in the Princess Margaret cohort study and the NCIC clinical trials group BR.24 trial of platinum-treated advanced stage non-small cell lung cancer patients. Cancer Epidemiology 41:50-56, 2016

  45. Martin P, Brown MC, Espin-Garcia O, Cuffe S, Pringle D, Mahler M, Villeneuve J, Niu C, Charow R, Lam C, Shani RM, Hon H, Otsuka M, Xu W, Alibhai S, Jenkinson J, Liu G: Patient preference: a comparison of electronic patient-completed questionnaires with paper among cancer patients. European journal of cancer care 25:334-341, 2016

  46. Naik H, Qiu X, Brown MC, Eng L, Pringle D, Mahler M, Hon H, Tiessen K, Thai H, Ho V, Gonos C, Charow R, Pat V, Irwin M, Herzog L, Ho A, Xu W, Jones JM, Howell D, Liu G: Socioeconomic Status and Lifestyle Behaviours in Cancer Survivors: Smoking and Physical Activity. Current Oncology 23:e546, 2016

  47. Leung YW, Brown C, Cosio AP, Dobriyal A, Malik N, Pat V, Irwin M, Tomasini P, Liu G, Howell D: Feasibility and diagnostic accuracy of the Patient-Reported Outcomes Measurement Information System (PROMIS) item banks for routine surveillance of sleep and fatigue problems in ambulatory cancer care. Cancer 122:2906-2917, 2016

  48. Segedi M, Anderson LN, Espin-Garcia O, Borgida A, Bianco T, Cheng D, Chen Z, Patel D, Brown MC, Xu W, Reisman D, Gallinger S, Cotterchio M, Hung R, Liu G, Cleary SP: BRM polymorphisms, pancreatic cancer risk and survival. International Journal of Cancer 139:2474-2481, 2016

  49. Wang JR, Habbous S, Espin–Garcia O, Chen D, Huang SH, Simpson C, Xu W, Liu F-F, Brown DH, Gilbert RW, Gullane PJ, Irish JC, Goldstein DP, Liu G: Comorbidity and performance status as independent prognostic factors in patients with head and neck squamous cell carcinoma. Head & Neck 38:736-742, 2016

  50. Eng L, Azad AK, Qiu X, Kong QQ, Cheng D, Ying N, Tse A, Kuang Q, Dodbiba L, Renouf DJ, Marsh S, Savas S, Mackay HJ, Knox JJ, Darling GE, Wong RKS, Xu W, Liu G, Faluyi OO: Discovery and validation of vascular endothelial growth factor (VEGF) pathway polymorphisms in esophageal adenocarcinoma outcome. Carcinogenesis 36:956-962, 2015

  51. Cuffe S, Hon H, Tobros K, Espin-Garcia O, Brhane Y, Harland L, Fadhel E, Eng L, LaDelfa A, Waldron J, Siu LL, Chen BE, Xu W, Simmons C, Kassam Z, Montenegro A, Parulekar WR, Liu G: Cancer patients’ acceptability of incorporating an epidemiology questionnaire within a clinical trial. Clinical Trials 12:237-245, 2015

  52. Niu C, Eng L, Qiu X, Shen X, Espin-Garcia O, Song Y, Pringle D, Mahler M, Halytskyy O, Charow R, Lam C, Shani RM, Villeneuve J, Tiessen K, Brown MC, Selby P, Howell D, Jones JM, Xu W, Liu G, Alibhai SMH: Lifestyle Behaviors in Elderly Cancer Survivors: A Comparison With Middle-Age Cancer Survivors. Journal of Oncology Practice 11:e450-e459, 2015

  53. Stewart EL, Mascaux C, Pham N-A, Sakashita S, Sykes J, Kim L, Yanagawa N, Allo G, Ishizawa K, Wang D, Zhu C-Q, Li M, Ng C, Liu N, Pintilie M, Martin P, John T, Jurisica I, Leighl NB, Neel BG, Waddell TK, Shepherd FA, Liu G, Tsao M-S: Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma. Journal of Clinical Oncology 33:2472-2480, 2015

  54. Dodbiba L, Teichman J, Fleet A, Thai H, Starmans MHW, Navab R, Chen Z, Girgis H, Eng L, Espin-Garcia O, Shen X, Bandarchi B, Schwock J, Tsao M-S, El-Zimaity H, Der SD, Xu W, Bristow RG, Darling GE, Boutros PC, Ailles LE, Liu G: Appropriateness of Using Patient-Derived Xenograft Models for Pharmacologic Evaluation of Novel Therapies for Esophageal/Gastro-Esophageal Junction Cancers. PLoS One 10:e0121872, 2015

  55. Stewart EL, Tan SZ, Liu G, Tsao M-S: Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review. Translational Lung Cancer Research 4:67-81, 2015

  56. Graham DM, Isaranuwatchai W, Habbous S, de Oliveira C, Liu G, Siu LL, Hoch JS: A cost-effectiveness analysis of human papillomavirus vaccination of boys for the prevention of oropharyngeal cancer. Cancer 121:1785-92, 2015

  57. Huang SH, Waldron JN, Milosevic M, Shen X, Ringash J, Su J, Tong L, Perez-Ordonez B, Weinreb I, Bayley AJ, Kim J, Hope A, Cho BCJ, Giuliani M, Razak A, Goldstein D, Shi W, Liu F-F, Xu W, O'Sullivan B: Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status. Cancer 121:545-555, 2015

  58. Moradian S, Howell D: Prevention and management of chemotherapy-induced nausea and vomiting. International Journal of Palliative Nursing 21:216-224, 2015

  59. Eng L, Qiu X, Su J, Pringle D, Niu C, Mahler M, Charow R, Villeneuve J, Halytskyy O, Lam C, Tiessen K, Brown MC, Howell D, Giuliani ME, Jones JM, Alibhai SMH, Goldstein DP, Xu W, Selby P, Liu G: The role of second-hand smoke exposure on smoking cessation in non–tobacco-related cancers. Cancer 121:2655-2663, 2015

  60. Lam C, Liu F, Bel RD, Chan K, Miller L, Brown MC, Chen Z, Cheng D, Patel D, Xu W, Darling GE, Liu G: Polymorphisms of the FOXF1 and MHC locus genes in individuals undergoing esophageal acid reflux assessments. Diseases of the Esophagus (in press), 2015

  61. Eng L, Su J, Qiu X, Palepu PR, Hon H, Fadhel E, Harland L, La Delfa A, Habbous S, Kashigar A, Cuffe S, Shepherd FA, Leighl NB, Pierre AF, Selby P, Goldstein DP, Xu W, Liu G: Second-Hand Smoke As a Predictor of Smoking Cessation Among Lung Cancer Survivors. Journal of Clinical Oncology 32:564-570, 2014

  62. Espin-Garcia O, Shen X, Qiu X, Brhane Y, Liu G, Xu W: Genetic association analysis for common variants in the Genetic Analysis Workshop 18 data (2012): a Dirichlet regression approach. BMC proceedings 8:S70-S70, 2014

  63. Shen X, Espin-Garcia O, Qiu X, Brhane Y, Liu G, Xu W: Haplotype approach for association analysis on hypertension (GWAS 2012 data). BMC proceedings 8:S57-S57, 2014

  64. Wong KM, Qiu X, Cheng D, Azad AK, Habbous S, Palepu P, Mirshams M, Patel D, Chen Z, Roberts H, Knox J, Marquez S, Wong R, Darling G, Waldron J, Goldstein D, Leighl N, Shepherd FA, Tsao M, Der S, Reisman D, Liu G: Two BRM promoter insertion polymorphisms increase the risk of early-stage upper aerodigestive tract cancers. Cancer Medicine 3:426-433, 2014

  65. Habbous S, Pang V, Xu W, Amir E, Liu G: Human papillomavirus and host genetic polymorphisms in carcinogenesis: A systematic review and meta-analysis. Journal of Clinical Virology 61:220-229, 2014

  66. Qiu X, Shen X, Espin-Garcia O, Azad AK, Liu G, Xu W: Genetic association analysis using weighted false discovery rate approach on Genetic Analysis Workshop 18 data (2012). BMC proceedings 8:S76-S76, 2014

  67. Bergman H, Walton T, Del Bel R, Seki JT, Rafii A, Xu W, Koren G, Shear N, Krzyzanowska MK, Howell D, Liu G: Managing skin toxicities related to panitumumab. Journal of the American Academy of Dermatology 71:754-759, 2014

  68. Cuffe S, Hon H, Qiu X, Tobros K, Wong C-KA, De Souza B, McFarlane G, Masroor S, Azad AK, Hasani E, Rozanec N, Leighl N, Alibhai S, Xu W, Issa AM, Liu G: Cancer patients’ acceptance, understanding, and willingness-to-pay for pharmacogenomic testing. Pharmacogenetics and Genomics 24:348-355, 2014

  69. Azad AK, Qiu X, Boyd K, Kuang Q, Emami M, Perera N, Palepu P, Patel D, Chen Z, Cheng D, Feld R, Leighl NB, Shepherd FA, Tsao M-S, Xu W, Liu G, Cuffe S: A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC). Lung Cancer 84:289-294, 2014

  70. Habbous S, Harland LTG, La Delfa A, Fadhel E, Xu W, Liu F-F, Goldstein D, Waldron J, Huang S-H, O'Sullivan B, Liu G: Comorbidity and prognosis in head and neck cancers: Differences by subsite, stage, and human papillomavirus status. Head & Neck 36:802-810, 2014

  71. Wang JR, Gramling SJB, Goldstein DP, Cheng D, Chen D, Azad AK, Tse A, Hon H, Chen Z, Mirshams M, Simpson C, Huang SH, Marquez S, O’Sullivan B, Liu F-F, Roberts H, Xu W, Brown DH, Gilbert RW, Gullane PJ, Irish JC, Reisman DN, Liu G: Association of two BRM promoter polymorphisms with head and neck squamous cell carcinoma risk. Carcinogenesis 34:1012-1017, 2013

  72. Eng L, Liu G: VEGF pathway polymorphisms as prognostic and pharmacogenetic factors in cancer: a 2013 update. Pharmacogenomics 14:1659-1667, 2013

  73. Kashigar A, Habbous S, Eng L, Irish B, Bissada E, Irish J, Brown D, Gilbert R, Gullane P, Xu W, Huang S-H, Witterick I, Freeman J, O'Sullivan B, Waldron J, Liu G, Goldstein D: Social environment, secondary smoking exposure, and smoking cessation among head and neck cancer patients. Cancer 119:2701-2709, 2013

  74. Habbous S, Chu KP, Harland LTG, La Delfa A, Fadhel E, Sun B, Xu W, Wong A, Howell D, Ringash J, Waldron J, O’Sullivan B, Goldstein D, Huang S-H, Liu G: Validation of a one-page patient-reported Charlson comorbidity index questionnaire for upper aerodigestive tract cancer patients. Oral oncology 49:407-412, 2013

  75. Habbous S, Chu KP, Qiu X, La Delfa A, Harland LTG, Fadhel E, Hui A, Perez-Ordonez B, Weinreb I, Liu F-F, Waldron J, O'Sullivan B, Goldstein D, Xu W, Huang SH, Liu G: The changing incidence of human papillomavirus-associated oropharyngeal cancer using multiple imputation from 2000 to 2010 at a Comprehensive Cancer Centre. Cancer Epidemiology 37:820-829, 2013

  76. Azad AK, Bairati I, Qiu X, Huang H, Cheng D, Liu G, Meyer F, Adjei A, Xu W: Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients. International Journal of Cancer 132:2520-2527, 2013

  77. Habbous S, Pang V, Eng L, Xu W, Kurtz G, Liu FF, Mackay HJ, Amir E, Liu G: p53 Arg72Pro Polymorphism, HPV status and Initiation, Progression, and Development of Cervical Cancer: A Systematic Review and Meta-analysis. Clinical Cancer Research, 2012

  78. Eng L, Azad AK, Habbous S, Pang V, Xu W, Maitland-van der Zee AH, Savas S, Mackay HJ, Amir E, Liu G: Vascular Endothelial Growth Factor Pathway Polymorphisms as Prognostic and Pharmacogenetic Factors in Cancer: A Systematic Review and Meta-analysis. Clinical Cancer Research, 2012

  79. Fehringer G, Liu G, Pintilie M, Sykes J, Cheng D, Liu N, Chen Z, Seymour L, Der SD, Shepherd FA, Tsao M-S, Hung RJ: Association of the 15q25 and 5p15 Lung Cancer Susceptibility Regions with Gene Expression in Lung Tumor Tissue. Cancer Epidemiology Biomarkers & Prevention 21:1097-1104, 2012

  80. Azad AK, Bairati I, Samson E, Cheng D, Mirshams M, Qiu X, Savas S, Waldron J, Wang C, Goldstein D, Xu W, Meyer F, Liu G: Validation of Genetic Sequence Variants as Prognostic Factors in Early-Stage Head and Neck Squamous Cell Cancer Survival. Clinical Cancer Research 18:196-206, 2012

  81. Diaz-Padilla I, Amir E, Marsh S, Liu G, Mackay H: Genetic polymorphisms as predictive and prognostic biomarkers in gynecological cancers: a systematic review. Gynecologic oncology 124:354-65, 2012

  82. Azad AK, Bairati I, Samson E, Cheng D, Cheng L, Mirshams M, Savas S, Waldron J, Wang C, Goldstein D, Xu W, Meyer F, Liu G: Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers. Cancer 118 1554-1565 2012

  83. Cheung WY, Zhai R, Bradbury P, Hopkins J, Kulke MH, Heist RS, Asomaning K, Ma C, Xu W, Wang Z, Hooshmand S, Su L, Christiani DC, Liu G: Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma. International Journal of Cancer 131:2478-2486, 2012

  84. Geraci J, Liu G, Jurisica I: Algorithms for systematic identification of small subgraphs. Methods in molecular biology (Clifton, N.J.) 804:219-44, 2012

  85. Horgan AMMBB, Leighl NBMD, Coate LMBB, Liu GMD, Palepu PMD, Knox JJMD, Perera NB, Emami MMD, Alibhai SMHMD: Impact and Feasibility of a Comprehensive Geriatric Assessment in the Oncology Setting: A Pilot Study. American Journal of Clinical Oncology 35:322-328, 2012

  86. Renouf D, Welch S, Moore M, Krzyzanowska M, Knox J, Feld R, Liu G, MacKay H, Petronis J, Wang L, Chen E: A phase II study of capecitabine, irinotecan, and bevacizumab in patients with previously untreated metastatic colorectal cancer. Cancer Chemotherapy and Pharmacology 69:1339-1344, 2012

  87. Coate LE, Massey C, Hope A, Sacher A, Barrett K, Pierre A, Leighl N, Brade A, de Perrot M, Waddell T, Liu G, Feld R, Burkes R, Cho BC, Darling G, Sun A, Keshavjee S, Bezjak A, Shepherd FA: Treatment of the elderly when cure is the goal: the influence of age on treatment selection and efficacy for stage III non-small cell lung cancer. Journal of Thoracic Oncology 6:537-44, 2011

  88. Ter-Minassian M, Wang Z, Asomaning K, Wu MC, Liu C-Y, Paulus JK, Liu G, Bradbury PA, Zhai R, Su L, Frauenhoffer CS, Hooshmand SM, De Vivo I, Lin X, Christiani DC, Kulke MH: Genetic associations with sporadic neuroendocrine tumor risk. Carcinogenesis 32:1216-1222, 2011

  89. Horgan AM, Knox JJ, Liu G, Sahi C, Bradbury PA, Leighl NB: Capecitabine or infusional 5-fluorouracil for gastroesophageal cancer: a cost-consequence analysis. Current Oncology 18:e64-70, 2011

  90. Liu G, Gramling S, Munoz D, Cheng D, Azad AK, Mirshams M, Chen Z, Xu W, Roberts H, Shepherd FA, Tsao MS, Reisman D: Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk. Oncogene 30:3295-3304, 2011

  91. Horgan AM, Yang B, Azad AK, Amir E, John T, Cescon DW, Wheatley-Price P, Hung RJ, Shepherd FA, Liu G: Pharmacogenetic and Germline Prognostic Markers of Lung Cancer. Journal of Thoracic Oncology 6:296-304, 2011

  92. Cheng L, Hu P, Sykes J, Pintilie M, Liu G, Xu W: A pathway-based association analysis model using common and rare variants. BMC proceedings 5 Suppl 9:S85, 2011

  93. Sykes J, Cheng L, Xu W, Tsao MS, Liu G, Pintilie M: Addition of multiple rare SNPs to known common variants improves the association between disease and gene in the Genetic Analysis Workshop 17 data. BMC proceedings 5 Suppl 9:S97, 2011

  94. Coate L, Cuffe S, Horgan A, Hung RJ, Christiani D, Liu G: Germline Genetic Variation, Cancer Outcome, and Pharmacogenetics. Journal of Clinical Oncology 28:4029-4037, 2010

  95. Wang Q, Wang A-h, Tan H-s, Feng N-n, Ye Y-j, Feng X-q, Liu G, Zheng Y-x, Xia Z-l: Genetic polymorphisms of DNA repair genes and chromosomal damage in workers exposed to 1,3-butadiene. Carcinogenesis 31:858-863, 2010

  96. Wheatley-Price P, Yang B, Patsios D, Patel D, Ma C, Xu W, Leighl N, Feld R, Cho BC, O'Sullivan B, Roberts H, Tsao MS, Tammemagi M, Anraku M, Chen Z, de Perrot M, Liu G: Soluble mesothelin-related Peptide and osteopontin as markers of response in malignant mesothelioma. Journal of Clinical Oncology 28:3316-22, 2010

  97. Chan K, Liu G, Miller L, Ma C, Xu W, Schlachta C, Darling G: Lack of Correlation Between a Self-Administered Subjective GERD Questionnaire and Pathologic GERD Diagnosed by 24-h Esophageal pH Monitoring. Journal of Gastrointestinal Surgery 14:427-436, 2010

  98. Savas S, Geraci J, Jurisica I, Liu G: A comprehensive catalogue of functional genetic variations in the EGFR pathway: protein-protein interaction analysis reveals novel genes and polymorphisms important for cancer research. International Journal of Cancer 125:1257-65, 2009

  99. Savas S, Liu G: Genetic variations as cancer prognostic markers: review and update. Human Mutation 30:1369-77, 2009

  100. Cescon DW, Bradbury PA, Asomaning K, Hopkins J, Zhai R, Zhou W, Wang Z, Kulke M, Su L, Ma C, Xu W, Marshall AL, Heist RS, Wain JC, Lynch TJ, Jr., Christiani DC, Liu G: p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis. Clinical Cancer Research 15:3103-9, 2009

  101. Bradbury PA, Zhai R, Hopkins J, Kulke MH, Heist RS, Singh S, Zhou W, Ma C, Xu W, Asomaning K, Ter-Minassian M, Wang Z, Su L, Christiani DC, Liu G: Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis. Carcinogenesis 30:793-8, 2009

  102. Bradbury PA, Zhai R, Ma C, Xu W, Hopkins J, Kulke MJ, Asomaning K, Wang Z, Su L, Heist RS, Lynch TJ, Wain JC, Christiani D, Liu G: Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis. Clinical Cancer Research 15:4680-5, 2009

  103. Savas S, Liu G: Studying genetic variations in cancer prognosis (and risk): a primer for clinicians. Oncologist 14:657-66, 2009

  104. Cheung WY, Zhai R, Kulke MH, Heist RS, Asomaning K, Ma C, Wang Z, Su L, Lanuti M, Tanabe KK, Christiani DC, Liu G: Epidermal growth factor A61G gene polymorphism, gastroesophageal reflux disease and esophageal adenocarcinoma risk. Carcinogenesis 30:1363-1367, 2009

  105. Bradbury PA, Kulke MH, Heist RS, Zhou W, Ma C, Xu W, Marshall AL, Zhai R, Hooshmand SM, Asomaning K, Su L, Shepherd FA, Lynch TJ, Wain JC, Christiani DC, Liu G: Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes. Pharmacogenet Genomics 19:613-25, 2009

  106. Cheung WY, Liu G: Genetic Variations in Esophageal Cancer Risk and Prognosis. Gastroenterology Clinics of North America 38:75-91, 2009

  107. Hopkins J, Cescon DW, Tse D, Bradbury P, Xu W, Ma C, Wheatley-Price P, Waldron J, Goldstein D, Meyer F, Bairati I, Liu G: Genetic Polymorphisms and Head and Neck Cancer Outcomes: A Review. Cancer Epidemiology Biomarkers & Prevention 17:490-499, 2008

  108. Wheatley-Price P, Asomaning K, Reid A, Zhai R, Su L, Zhou W, Zhu A, Ryan DP, Christiani DC, Liu G: Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Cancer 112:1037-42, 2008

  109. Bradbury PA, Heist RS, Kulke MH, Zhou W, Marshall AL, Miller DP, Su L, Park S, Temel J, Fidias P, Sequist L, Lynch TJ, Wain JC, Shepherd FA, Christiani DC, Liu G: A Rapid Outcomes Ascertainment System Improves the Quality of Prognostic and Pharmacogenetic Outcomes from Observational Studies. Cancer Epidemiology Biomarkers & Prevention 17:204-211, 2008

  110. Fruh M, Zhou W, Zhai R, Su L, Heist RS, Wain JC, Nishioka NS, Lynch TJ, Shepherd FA, Christiani DC, Liu G: Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma. British Journal of Cancer 98:689-92, 2008

  111. Liu G, Wheatley-Price P, Zhou W, Park S, Heist RS, Asomaning K, Wain JC, Lynch TJ, Su L, Christiani DC: Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk. International Journal of Cancer 122:915-8, 2008

  112. Tse D, Zhai R, Zhou W, Heist RS, Asomaning K, Su L, Lynch TJ, Wain JC, Christiani DC, Liu G: Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk. Cancer Causes & Control 19:1077-83, 2008