About the Liu Lab

Liu Lab

The Geoffrey Liu laboratory is a multidisciplinary, collaborative translational laboratory that seeks to improve outcomes in cancer. The laboratory has four main programs and a multi-level training program:

AMP-PEL program:

stands for Applied Molecular, Pharmacoepidemiologic, Pharmacogenomic, and Epidemiologic Laboratory, and focuses on identifying and validating cancer biomarkers:

Project 1: OPTIMAL:Organoids to guide Post-resistanceTherapyIn driver MutAtedLung cancers which utilizes the PALMS(PAtient-derivedLung cancer ModelS) gold cohort of data and samples
Project 2: human population studies (COS-ILCCO: Clinical Outcomes Studies of the International Lung Cancer Consortium Studies of Clinical Outcomes) and understanding
Project 3: developing improved patient phenotyping of symptoms and toxicities: (2BLAST: Biostatistical and Bioinformatic Longitudinal Assessment of Symptoms and Toxicities)
Project 4: PRALINES: PRincess Margaret Adenocarcinoma of Lung cancer In Never smokErs Study, which utilizes the ALINE (Adenocarcinoma of Lung cancer In Never smokEr) gold cohort of data and samples
Project 5: CPHIN Lung KSP: Canadian Personalized Healthcare Innovation Network Lung cancer Kick Start Program

CALIBRE program:

stands for Clinical And LIquid biopsy, Breathomics, and Radiomics for Early detection of Cancer

Project 1: Clinical and Implementation Studies in Lung Cancer Screening
Project 2: Radiomics in Lung Cancer Screening
Project 3: Liquid Biopsies in Lung Cancer in Early Detection
Project 4: Breathomics in Lung Cancer Early Detection
Project 5: CALIBRE Integrative Analysis for Lung Cancer Screening

AIM REDUCE program:

stands for An Intelligent Machine-learning Model for Real-time Early Detection of Undesirable Cancer Events

Project 1: Natural language processing (NLP) methodologies to extract accurate and detailed information from radiology reports
Project 2: NLP methodologies to identify the presence of precancerous lesions in surgical pathology reports

ON-PROST program:

stands for ONtario Patient Reported Outcomes of Symptoms and Toxicity

CLINTA stands for CLInic-based New Technology Applications

Project 1: SPOCH: Serial Point-Of-CareHearing tests for ototoxic cancertherapies
Project 2: STAQ-home: Symptoms, Toxicities And Quality-of-Life data collection at home
Project 3: EPEQ: ElectronicPlatforms for EpidemiologyQuestionnaires

CHUQoLS (pronounced Chuckles) which stands for Cancer Health Utilities and Quality of Life Studies

Project 1: CARMA BROS: the CAnadian RareMolecular Alterations Basket Real-world Observational Study
Project 2: PALEOS: PAn-Canadian Lung cancEr Observational Study
Project 3 CASCADE: Canadian Small cell lung cAncer DatabasE

HANG-OUT program:

stands for Head And Neck cancer network for Genetics, Observational oUtcomes, and Toxicities: A combined OPTIMAL and ON-PROST initiative

Project 1: GENE-SMOKE:

Genetics of Smoking Outcomes and Knowledge Effects

Project 2: GENE-LAST:

Genetics of Long and Short-term Toxicities

Project 3: VOYAGER consortium: humanpapilloma Virus, Oral and oropharYngeal cAncer, GEnomicsand suRvival
Project 4: ENHANCE consortium: International Head And Neck Cancer Epidemiology Consortium

SHINES:

The Screening High-risk Individuals who Never Smoked (SHINES) Study is investigating what risk factors aside from smoking influence lung cancer development.

CARMA:

Canadian Rare Molecular Alteration Basket Real-world Observational Study is the first basket observational cancer study in Canada. Subsets of patients in this first round of study include ALK, ROS1, BRAF, and EGFR exon 20. Additional molecular baskets may be added over time, depending on funding.

COMBIEL Training Program: Cancer Outcomes, Medicine, Biostatistics, Informatics, EpidemiologyLaboratory Training Program (see www.uhncombiel.com for details)